AUTOLOGOUS MARROW TRANSPLANTATION IN THE TREATMENT OF MOPP AND ABVD-RESI STANT HODGKIN\'S DISEASE
نویسنده
چکیده مقاله:
Six patients with disseminated Hodgkin's disease resistant to MOPP (mechlorethamine, vincristine, procarbazine and prednisolone), and ABVD (adriamycin, bleomycin, vinblastine and dacarbazine) chemotherapy were treated with high-dose chemotherapy and autologous marrow transplantation. The patients first underwent marrow aspiration and storage for subsequent autologous bone marrow transplantation (AB MT). Three patients remain alive in unmaintained complete remission (CR) at I X, 17, and 15 months after transplant. In the other three patients, reasons for faiJure included relapse in two patients after 7 and g months, and death after 6 months due to pulmonary infection (pneumonia). These results demonstrate that some patients with MOPP, ABVD and other salvage chemotherapy (SC)-resistant Hodgkin's disease can obtain prolonged complete remission following intensive chemotherapy and autologous marrow transplantation
منابع مشابه
autologous marrow transplantation in the treatment of mopp and abvd-resi stant hodgkin's disease
six patients with disseminated hodgkin's disease resistant to mopp (mechlorethamine, vincristine, procarbazine and prednisolone), and abvd (adriamycin, bleomycin, vinblastine and dacarbazine) chemotherapy were treated with high-dose chemotherapy and autologous marrow transplantation. the patients first underwent marrow aspiration and storage for subsequent autologous bone marrow transplant...
متن کاملRandomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: report of an intergroup trial.
PURPOSE In a series of trials, doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and mechlorethamine, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (MOPP/ABV) have been identified as effective treatments for Hodgkin's disease. We compared these regimens as initial chemotherapy for Hodgkin's disease. PATIENTS AND METHODS Adult patients (N = 856) with ...
متن کامل[Autologous bone marrow transplantation].
By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the e...
متن کامل[Autologous bone marrow transplantation].
By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the e...
متن کاملSuccessful treatment of refractory Hodgkin's disease by high-dose combination chemotherapy and autologous bone marrow transplantation.
Forty-four patients with refractory Hodgkin's disease were treated with high-dose combination chemotherapy followed by autologous bone marrow rescue. Twenty-two patients (50%) entered complete remission within 6 months of the procedure and four other patients are free of disease progression. Only two patients have subsequently relapsed from complete remission (CR). Bone marrow suppression was t...
متن کاملTreatment of progressive Hodgkin's disease with intensive chemoradiotherapy and autologous bone marrow transplantation.
Twenty-six patients with progressive Hodgkin's disease after conventional chemotherapy received intensive chemoradiotherapy and autologous bone marrow transplantation (ABMT); 19 also received additional involved-field radiotherapy. Twenty-one patients [81%, 95% confidence intervals (CI) 61% to 94%] attained complete (n = 18) or partial responses. Ten patients (38%, 95% CI 20% to 59%) are diseas...
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عنوان ژورنال
دوره 8 شماره 1
صفحات 9- 16
تاریخ انتشار 1994-05
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